205/1, 3rd Main Road, Chamrajpet, Bengaluru 560018 | Mon–Sat: 9:30 AM – 7:00 PM
Graft Biomaterials
InterOss Anorganic Cancellous Granules — product box front
InterOss Anorganic Cancellous Granules — product box angle
Box front
Box angle
Graft Biomaterials

InterOss®

Anorganic Cancellous Bone Granules — Natural Hydroxyapatite for Predictable Bone Regeneration

100% Hydroxyapatite Osteoconductive Biocompatible Micro & Macro Porous Vial & Syringe Forms 6–9 Month Integration

InterOss® is a natural hydroxyapatite bone grafting material made from a proven multi-step purification process, leaving only a pure bone mineral composition. Chemically and structurally comparable to mineralised human bone, it features an interconnected network of macro and micro pores that create an ideal environment for cell attachment, vascularisation, and new bone formation. Available in sterilised granule form in vials and syringes for single use.

Download Product Brochure (PDF)
Genuine Graft Biomaterials
Pan-India Delivery
Sterile, Single-Use
Clinical Support
100% Pure Hydroxyapatite — Mineral Phase Osteoconductive — Clinically Validated Macro & Micro Porous Structure Available in Vial & Syringe Forms 6–9 Month Integration Time Available in India — AJJA Dental Solution 100% Pure Hydroxyapatite — Mineral Phase Osteoconductive — Clinically Validated Macro & Micro Porous Structure Available in Vial & Syringe Forms 6–9 Month Integration Time Available in India — AJJA Dental Solution
Key Facts

InterOss® at a Glance

100%Pure Hydroxyapatite — Mineral Phase
6–9Month Integration Time
2×More Bone vs Bio-Oss® at 8 & 12 Weeks*
54+Preclinical Sites — Osteoconductivity Confirmed

*Histomorphometry data from comparative preclinical study (InterOss® vs Bio-Oss®). Not statistically significant.

Features & Benefits

Engineered for Bone Regeneration

InterOss® combines the proven osteoconductive properties of natural bovine hydroxyapatite with a unique pore structure that closely mimics human cancellous bone — creating the ideal biological scaffold.

Biocompatible — Extremely Low Organics
Produced through a long annealing purification process, Thermogravimetric Analysis confirms an extremely low residual organic content — only pure, safe bone mineral remains for confident clinical use.
Micro & Macro Porous Architecture
Microporosity (3 μm scale) facilitates osteoblast proliferation. Macroporosity (300 μm scale) allows vascularisation and plays a critical role in osteoconductivity. Mesopores increase inner surface area, enhancing bone ingrowth inside the pores.
Osteoconductive — Clinically Validated
A preclinical trial across 54 mandibular ridge defects in 27 canines confirmed successful new bone formation. By 8 weeks, significant new bone was present; at 12 weeks, mature bone formation was observed — clinically and histologically successful.
Slow Degradation — Long-Term Stability
Bovine hydroxyapatite provides an osteoconductive surface enabling slow, controlled degradation and enhanced osseointegration of particles into new bone. The material's long-term stability supports complex augmentation cases.
Compatible with Allograft & Autologous Bone
InterOss® can be combined with allograft for enhanced bone regeneration potential, or with autologous bone to leverage osteoinductivity and osteogenesis for faster, more complete regeneration.

Product Properties

InterOss® — Anorganic Cancellous Granules

Composition
Calcium phosphate — 100% pure hydroxyapatite (mineral phase)
Source
Bovine — anorganic (fully purified)
Integration Time
6–9 months (depending on defect size and patient)
Storage Temp
59–77 °F / 15–25 °C
Degradation Profile
Slow degradation — enhanced osseointegration of particles into new bone
Pore Structure
Interconnected macro & micro pores (30 μm — 3 μm — 300 μm)
Granule Sizes
Small: 0.25–1.0 mm / Large: 1.0–2.0 mm
Forms
Sterilised vial & syringe
Usage
Single use
Hydration
Blood or sterile saline solution
Healing Re-entry
Minimum 6 months recommended
Manufacturer
SigmaGraft / Graft Biomaterials
Indications for Use

Where InterOss® Works Best

InterOss® is indicated across the full spectrum of bone regeneration procedures in implant, periodontal, and oral surgery.

Socket Preservation

Augmentation or reconstructive treatment of the alveolar ridge, including filling of extraction sockets to maintain ridge volume for future implant placement.

Periodontal Defects

Filling of infrabony periodontal defects in conjunction with products intended for guided tissue regeneration (GTR) and guided bone regeneration (GBR).

Sinus Floor Elevation

Elevation of the maxillary sinus floor (lateral window or crestal approach) to provide sufficient bone height and volume for implant placement in the posterior maxilla.

Peri-Implant Defects

Filling of peri-implant defects in conjunction with guided bone regeneration products — supporting osseointegration around implants in compromised sites.

Post-Surgical Defects

Filling of defects following root resection, apicoectomy, and cystectomy — where precise, stable graft placement is required for predictable healing.

GBR & Ridge Augmentation

Horizontal and vertical ridge augmentation procedures, used alone or in combination with autologous bone or allograft, with or without a collagen membrane barrier.

Product Options

Available in Vial & Syringe

InterOss® is available in two granule sizes and two delivery formats — choose the right volume and format for your surgical indication.

Small Granules (0.25–1.0 mm)

Ideal for smaller defects, socket preservation, and precise placement

SKU (Vial)VolumeWeightSKU (Syringe)Volume
IOSG0250.54 cc0.25 gIOSGS0250.25 cc
IOSG0501.08 cc0.5 gIOSGS0500.5 cc
IOSG1002.16 cc1.0 gIOSGS1001.0 cc
IOSG2004.32 cc2.0 g

Large Granules (1.0–2.0 mm)

Suitable for larger defects, sinus augmentation, and ridge build-up

SKU (Vial)VolumeWeightSKU (Syringe)Volume
IOLG0502.0 cc0.5 gIOLGS0500.5 cc
IOLG1004.0 cc1.0 gIOLGS1001.0 cc
IOLG2008.0 cc2.0 g
Application & Handling

Simple Protocol, Predictable Results

1

Hydration

Hydrate InterOss® granules in blood or sterile saline solution prior to placement for optimal consistency and handling.

2

Placement

Administer to the surgical site using a surgical currette or periosteal elevator. Ensure the graft material makes sufficient contact with the bleeding bone surface to facilitate ingrowth of new blood vessels and bone-forming cells.

3

Membrane Coverage

A resorbable membrane (such as InterCollagen® Guide) should be placed over the graft material to minimise particulate migration and guide bone regeneration.

4

Wound Closure

Ensure that the grafted site is securely closed with soft tissue free of tension to support undisturbed healing and graft stability.

5

Healing & Re-entry

Allow at least 6 months of healing before re-entry to ensure complete graft integration. Healing time varies by defect size and patient biology.

Material Properties

Composition
Calcium phosphate — 100% pure hydroxyapatite (mineral phase)
Integration Time
6–9 months (defect dependent)
Storage Temperature
59–77 °F / 15–25 °C
Degradation Profile
Slow degradation with enhanced osseointegration of particles into new bone via bovine hydroxyapatite osteoconductive surface
Pore Scale
30 μm (mesopores) · 3 μm (micropores) · 300 μm (macropores)
Compatibility
Autologous bone / Allograft / Resorbable membranes
Brochure & Enquiry

Download & Get in Touch

Product Brochure

Download the complete InterOss® GBR Materials brochure — full product specifications, indications, application protocol, comparative clinical data, granule size options, and clinical case studies from leading dental institutions.

PDF Format English Official Graft Biomaterials
Download Brochure — Free

Interested? Let's Talk.

Get pricing, availability, and clinical support for InterOss® granules in India. Our team is available Mon–Sat, 9:30 AM – 7:00 PM from Bengaluru.